Prognostic importance of human papillomavirus type 16 DNA in cervical cancer
نویسندگان
چکیده
منابع مشابه
Integration of human papillomavirus type 16 in cervical cancer cells
Cervical cancer remains an important cause of women morbidity and mortality. The progression of cervical pathology correlates with the HPV integration into the host genome. However, the data on the viral integration status in cervical dysplasias are controversial. The aim of the current study was to evaluate the status of HPV integration in two types of cervical pathology - invasive and non inv...
متن کاملHuman papillomavirus type 16 variants and risk of cervical cancer.
There are substantial data demonstrating that human papillomaviruses (HPVs) are the sexually transmitted etiologic agents of cervical cancer (1). HPV type 16 (HPV16) is the most common HPV type detected in tumors, accounting for 50% of cancers and their precursors, called high-grade squamous intraepithelial lesions (HSILs) (2). Preliminary studies (3–16) have suggested that variants of HPV16 ma...
متن کاملConstruction a DNA Vaccine Containing Human Papillomavirus Type 16 Early Genes as a Potential Vaccine for Cervical Cancer Prevention and Therapy
Background and Objectives: Some of the human papillomaviruses (HPVs) can infect genital tracts and are sometimes associated with anogenital tract cancers. HPVs induced cervical cancers through the expression of E6 and E7 genes by inactivating the tumor suppressor proteins. In this study, E6 and E7 genes were chosen in order to construct an expression vector which is able to express ...
متن کاملHuman papillomavirus L1 capsid protein and human papillomavirus type 16 as prognostic markers in cervical intraepithelial neoplasia 1.
INTRODUCTION The aim of the study was to determine whether human papillomavirus (HPV) L1 capsid protein and the HPV genotype can predict the disease course as prognostic markers for cervical intraepithelial neoplasia 1 (CIN1). METHODS Immunohistochemical staining was performed for HPV L1 capsid protein in 101 women who had been confirmed to have CIN1 by histologic examination and HPV high-ris...
متن کاملConserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia.
DNA methylation contributes to the chromatin conformation that represses transcription of human papillomavirus type16 (HPV-16), which is prevalent in the etiology of cervical carcinoma. In an effort to clarify the role of this phenomenon in the regulation and carcinogenicity of HPV-16, 115 clinical samples were studied to establish the methylation patterns of the 19 CpG dinucleotides within the...
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ژورنال
عنوان ژورنال: Cancer
سال: 1992
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19920515)69:10<2502::aid-cncr2820691019>3.0.co;2-7